RNA-Puzzles
is a collective experiment for blind RNA structure prediction.
Aims of the project
To determine the capabilities and limitations of current methods of 3D RNA structure prediction based on sequence;
To find whether and how progress has been made, as well as what has yet to be done to achieve better solutions
To identify whether there are specific bottlenecks that hold back the field;
To promote the available methods and guide potential users in the choice of suitable tools for real-world problems;
To encourage the RNA structure prediction community in their efforts to improve the current tools and to make automated prediction tools available.
To explore the underlying mechanism of ligand-RNA binding and the conformational changes in riboswitches.
Basic Rules
Confidential agreement: "I will use the provided sequence data for prediction purposes only. I will not distribute the sequences in any form outside my working group."
It is strongly recommanded that all the predictions formatted in standard PDB format. So that all the modellers could have a fair comparison without considering the file format and prediction region. We provide a python script here for generating standard PDB format files, only the coordinates need to be replaced by the predictors.
RNA chains should be named in alphabetical order. e.g. A for the first chain, B for the second chain.
Up to FIVE prediction models could be predicted as the final results of one problem for each group. It is also recommended to submit ten models.
Please put all prediction models together in one PDB file as NMR format (Separate models by lines: "MODEL n" and "ENDMDL").
For submission, please either use our online submission system or send us an email.
Call for participants
We hope more crystallgraphers could help us in providing more crystal, cryo-EM or NMR structures. Any kind of RNA related structure information is encouraged. Anyone who may have a RNA structure please contact us.
We encourage more predictors who are interested in RNA structure prediction to take part in this compitition to push forward the field. Anyone who is interested please send us an email.